Publications

Latest

Effect of Caffeine and Other Methylxanthines on Aβ-Homeostasis in SH-SY5Y Cells.
Selected as cover story for Biomolecules November 2019 Issue
Janitschke D,
Nelke C,
Lauer AA,
Regner L,
Winkler J,
Thiel A,
Grimm HS,
Hartmann T,
Grimm MOW.
Pubmed
The Effects of Vitamin D Deficiency on Neurodegenerative Diseases.
Lauer AA,
Janitschke D,
Hartmann T,
Grimm HS,
Grimm MOW.
IntechOpen BookChapter
Profiling of Alzheimer's disease related genes in mild to moderate vitamin D hypovitaminosis.
Grimm MOW,
Lauer AA,
Grösgen S,
Thiel A,
Lehmann J,
Winkler J,
Janitschke D,
Beisswenger C,
Bals R,
Grimm HS,
Hartmann T.
Pubmed
Transcriptional repression of the ectodomain sheddase ADAM10 by TBX2 and potential implication for Alzheimer's disease.
Reinhardt S,
Schuck F,
Stoye N,
Hartmann T,
Grimm MOW,
Pflugfelder G,
Endres K.
Pubmed
Paradoxical effects of mutant ubiquitin on Aβ plaque formation in an Alzheimer mouse model.
Verheijen BM,
Stevens JAA,
Gentier RJG,
van 't Hekke CD,
van den Hove DLA,
Hermes DJHP,
Steinbusch HWM,
Ruijter JM,
Grimm MOW,
Haupenthal VJ,
Annaert W,
Hartmann T,
van Leeuwen FW.
Pubmed
Vitamin D and Its Analogues Decrease Amyloid-β (Aβ) Formation and Increase Aβ-Degradation.
Grimm MOW,
Thiel A,
Lauer AA,
Winkler J,
Lehmann J,
Regner L,
Nelke C,
Janitschke D,
Benoist C,
Streidenberger O,
Stötzel H,
Endres K,
Herr C,
Beisswenger C,
Grimm HS,
Bals R,
Lammert F,
Hartmann T.
Pubmed
24-month intervention with a specific multinutrient in people with prodromal Alzheimer's disease (LipiDiDiet): a randomised, double-blind, controlled trial.
Soininen H,
Solomon A,
Visser PJ,
Hendrix SB,
Blennow K,
Kivipelto M,
Hartmann T;
LipiDiDiet clinical study group.
Pubmed
Omega-3 fatty acids, lipids, and apoE lipidation in Alzheimer's disease: a rationale for multi-nutrient dementia prevention.
Grimm MOW,
Michaelson DM,
Hartmann T.
Pubmed
APP Function and Lipids: A Bidirectional Link.
Grimm MOW,
Mett J,
Grimm HS,
Hartmann T.
Pubmed
Altered Gut Microbiome Composition and Tryptic Activity of the 5xFAD Alzheimer's Mouse Model.
Brandscheid C,
Schuck F,
Reinhardt S,
Schäfer KH,
Pietrzik CU,
Grimm MOW,
Hartmann T,
Schwiertz A,
Endres K.
Pubmed
Eicosapentaenoic acid and docosahexaenoic acid increase the degradation of amyloid-β by affecting insulin-degrading enzyme.
Grimm MO,
Mett J,
Stahlmann CP,
Haupenthal VJ,
Blümel T,
Stötzel H,
Grimm HS,
Hartmann T.
Pubmed
Tocotrienol Affects Oxidative Stress, Cholesterol Homeostasis and the Amyloidogenic Pathway in Neuroblastoma Cells: Consequences for Alzheimer's Disease.
Grimm MO,
Regner L,
Mett J,
Stahlmann CP,
Schorr P,
Nelke C,
Streidenberger O,
Stoetzel H,
Winkler J,
Zaidan SR,
Thiel A,
Endres K,
Grimm HS,
Volmer DA,
Hartmann T.
Pubmed
Sphingomyelin Synthase 1 Is Essential for Male Fertility in Mice.
Wittmann A,
Grimm MO,
Scherthan H,
Horsch M,
Beckers J,
Fuchs H,
Gailus-Durner V,
Hrabě de Angelis M,
Ford SJ,
Burton NC,
Razansky D,
Trümbach D,
Aichler M,
Walch AK,
Calzada-Wack J,
Neff F,
Wurst W,
Hartmann T,
Floss T.
Pubmed
The Impact of Vitamin E and Other Fat-Soluble Vitamins on Alzheimer´s Disease.
Grimm MO,
Mett J,
Hartmann T.
Pubmed
Transnasal delivery of human A-beta peptides elicits impaired learning and memory performance in wild type mice.
Endres K,
Reinhardt S,
Geladaris A,
Knies J,
Grimm M,
Hartmann T,
Schmitt U.
Pubmed
Rescue of Hypovitaminosis A Induces Non-Amyloidogenic Amyloid Precursor Protein (APP) Processing.
Reinhardt S,
Grimm MO,
Stahlmann C,
Hartmann T,
Shudo K,
Tomita T,
Endres K.
Pubmed
Oxidized Docosahexaenoic Acid Species and Lipid Peroxidation Products Increase Amyloidogenic Amyloid Precursor Protein Processing.
Grimm MO,
Haupenthal VJ,
Mett J,
Stahlmann CP,
Blümel T,
Mylonas NT,
Endres K,
Grimm HS,
Hartmann T.
Pubmed

2015-2010

Grimm MO, Mett J, Stahlmann CP, Grösgen S, Haupenthal VJ, Blümel T, Hundsdörfer B, Zimmer VC, Mylonas NT, Tanila H, Müller U, Grimm HS, Hartmann T (2015). APP intracellular domain derived from amyloidogenic β- and γ-secretase cleavage regulates neprilysin expression. Front Aging Neurosci., 7:77. Pubmed

Grimm MO, Stahlmann CP, Mett J, Haupenthal VJ, Zimmer VC, Lehmann J, Hundsdörfer B, Endres K, Grimm HS, Hartmann T (2015). Vitamin E: Curse or Benefit in Alzheimer's Disease? A Systematic Investigation of the Impact of α-, γ- and δ-Tocopherol on Aß Generation and Degradation in Neuroblastoma Cells. J Nutr Health Aging., 19(6):646-56. Pubmed

Blacher E, Dadali T, Bespalko A, Haupenthal VJ, Grimm MO, Hartmann T, Lund FE, Stein R, Levy A (2015). Alzheimer's disease pathology is attenuated in a CD38-deficient mouse model. Ann Neurol., 78(1):88-103. Pubmed

Grimm MO, Hundsdörfer B, Grösgen S, Mett J, Zimmer VC, Stahlmann CP, Haupenthal VJ, Rothhaar TL, Lehmann J, Pätzold A, Zinser EG, Tanila H, Shen J, Müller U, Grimm HS, Hartmann T (2014). PS Dependent APP Cleavage Regulates Glucosylceramide Synthase and is Affected in Alzheimer's Disease., Cell Physiol Biochem., 34(1):92-110. Pubmed

Karaca I, Tamboli IY, Glebov K, Richter J, Fell LH, Grimm MO, Haupenthal VJ, Hartmann T, Gräler MH, van Echten-Deckert G, Walter J (2014). Deficiency of Sphingosine-1-phosphate Lyase Impairs Lysosomal Metabolism of the Amyloid Precursor Protein., J Biol Chem., 289(24):16761-16772. Pubmed

Grimm MO, Zimmer VC, Lehmann J, Grimm HS, Hartmann T (2013). The impact of cholesterol, DHA, and sphingolipids on Alzheimer's disease., Biomed Res Int. 2013:814390. Pubmed

Koivisto H, Grimm MO, Rothhaar TL, Berkecz R, Lütjohann DD, Giniatullina R, Takalo M, Miettinen PO, Lahtinen HM, Giniatullin R, Penke B, Janáky T, Broersen LM, Hartmann T, Tanila H (2014). Special lipid-based diets alleviate cognitive deficits in the APPswe/PS1dE9 transgenic mouse model of Alzheimer's disease independent of brain amyloid deposition., J Nutr Biochem. 25(2):157-69. Pubmed

Grimm MO, Mett J, Stahlmann CP, Haupenthal VJ, Zimmer VC, Hartmann T (2013). Neprilysin and Aβ Clearance: Impact of the APP Intracellular Domain in NEP Regulation and Implications in Alzheimer's Disease., Front Aging Neurosci. 5:98. Pubmed

Robinson A, Grösgen S, Mett J, Zimmer VC, Haupenthal VJ, Hundsdörfer B, Stahlmann CP, Slobodskoy Y, Müller UC, Hartmann T, Stein R, Grimm MO (2014). Upregulation of PGC-1α expression by Alzheimer's disease-associated pathway: presenilin 1/amyloid precursor protein (APP)/intracellular domain of APP., Aging Cell. 13(2):263-72. Pubmed

Grimm MO, Lehmann J, Mett J, Zimmer VC, Grösgen S, Stahlmann CP, Hundsdörfer B, Haupenthal VJ, Rothhaar TL, Herr C, Bals R, Grimm HS, Hartmann T (2014). Impact of Vitamin D on amyloid precursor protein processing and amyloid-β peptide degradation in Alzheimer's disease., Neurodegener Dis. 13(2-3):75-81. Pubmed

Burg VK, Grimm HS, Rothhaar TL, Grösgen S, Hundsdörfer B, Haupenthal VJ, Zimmer VC, Mett J, Weingärtner O, Laufs U, Broersen LM, Tanila H, Vanmierlo T, Lütjohann D, Hartmann T, Grimm MO (2013). Plant sterols the better cholesterol in Alzheimer's disease? A mechanistical study., J Neurosci. 33(41):16072-87. Pubmed

Grimm MO, Haupenthal VJ, Rothhaar TL, Zimmer VC, Grösgen S, Hundsdörfer B, Lehmann J, Grimm HS, Hartmann T (2013). Effect of different phospholipids on α-secretase activity in the non-amyloidogenic pathway of Alzheimer´s disease., Int J Mol Sci, 14(3):5879-98. Pubmed

Grimm MO, Hartmann T (2012). Recent Understanding of the Molecular Mechanisms of Alzheimer’s Disease., J Addict Res Ther, S5:004, doi:10.4172/2155-6105.S5-004, in press.

Vanmierlo T, Weingärtner O, van der Pol S, Husche C, Kerksiek A, Friedrichs S, Sijbrands E, Steinbusch H, Grimm MO, Hartmann T, Laufs U, Böhm M, de Vries HE, Mulder M, Lütjohann D (2012). Dietary intake of plant sterols stably increases plant sterol levels in the murine brain., J Lipid Res, 53(4):726-35. Pubmed

Grimm MO, Zinser EG, Grösgen S, Hundsdörfer B, Rothhaar TL, Burg VK, Kaestner L, Bayer TA, Lipp P, Müller U, Grimm HS, Hartmann T (2012). Amyloid precursor protein (APP) mediated regulation of ganglioside homeostasis linking Alzheimer’s disease pathology with ganglioside metabolism., PLoS One. 7(3):e34095. Pubmed

Rothhaar TL, Grösgen S, Haupenthal VJ, Burg VK, Hundsdörfer B, Mett J, Riemenschneider M, Grimm HS, Hartmann T, Grimm MO (2012). Plasmalogens inhibit APP Processing by directly affecting gamma-secretase activity in Alzheimer´s Disease., ScientificWorldJournal, vol. 2012, Article ID 141240, doi:10.1100/2012/141240. Pubmed

Grimm MO, Rothhaar TL, Hartmann T (2011). The role of APP proteolytic processing in lipid metabolism., Exp Brain Res, doi:10.1007/s00221-011-2975-6. Pubmed

Grimm MO, Grösgen S, Riemenschneider M, Tanila H, Grimm HS, Hartmann T (2011). From brain to food: Analysis of Phosphatidylcholins, lyso-Phospatidylcholins and Phosphatidycholin-Plasmalogens derivates in Alzheimer's disease human post mortem brains and mice model via mass spectrometry., J Chromatogr A, 1218(42):7713-22. Pubmed

Schäfer KH, Braun A, Semar S, Letiembre M, Klotz M, Klein JC, Grimm MO, Micci MA, Taglialatela G, Liu Y, Fassbender K, Hartmann T (2011). Alzheimers Disease Affects the Enteric Nervous System., Gastroenterology, vol. 140, 5: S54-S54

Grimm MO, Rothhaar TL, Grösgen S, Burg VK, Hundsdörfer B, Haupenthal VJ, Friess P, Kins S, Grimm HS, Hartmann T (2011). Trans fatty acids enhance amyloidogenic processing of the Alzheimer Amyloid Precursor Protein (APP)., J Nutr Biochem, doi:10.1016/j.jnutbio.2011.06.015. Pubmed

Grimm MO, Grösgen S, Rothhaar TL, Burg VK, Hundsdörfer B, Haupenthal VJ, Friess P, Müller U, Fassbender K, Riemenschneider M, Grimm HS, Hartmann T (2011). Intracellular APP Domain Regulates Serine-Palmitoyl-CoA Transferase Expression and Is Affected in Alzheimer's Disease, Int J Alzheimers Dis, vol. 2011, Article ID 695413, doi:10.4061/2011/695413. Pubmed

Grimm MO, Kuchenbecker J, Grösgen S, Burg VK, Hundsdörfer B, Rothhaar TL, Friess P, de Wilde MC, Broersen LM, Penke B, Péter M, Vígh L, Grimm HS, Hartmann T (2011). Docosahexaenoic acid reduces amyloid beta production via multiple pleiotropic mechanisms, J Biol Chem, 286(16): 14028-14039. Pubmed

Grimm MO, Kuchenbecker J, Rothhaar TL, Grösgen S, Hundsdörfer B, Burg VK, Friess P, Müller U, Grimm HS, Riemenschneider M, Hartmann T (2011). Plasmalogen synthesis is regulated via alkyl-dihydroxyacetonephosphate-synthase by amyloid precursor protein processing and is affected in Alzheimer's disease, J Neurochem, 116(5): 916-925. Pubmed

Hao W, Liu Y, Liu S, Walter S, Grimm MO, Kiliaan AJ, Penke B, Hartmann T, Rübe CE, Menger MD, Fassbender K (2011). Myeloid differentiation factor 88-deficient bone marrow cells improve Alzheimer's disease-related symptoms and pathology, Brain, 134(Pt 1): 278-292. Pubmed



2006 - 2010
Grösgen S, Grimm MO, Friess P, Hartmann T (2010). Role of amyloid beta in lipid homeostasis, Biochim Biophys Acta, 1801(8): 966-974. Pubmed

Grimm MO, Grösgen S, Hartmann T (2009). Link between Gangliosides, Sphingolipids and Alzheimer’s Disease in 9th International Conference on Alzheimer´s and Parkinson´s Disease AD/PD. (eds. A. Fisher & I. Hanin), 317-320. (Medimond International Proceedings, Praque, Czech Republic)

Grimm MO, Tschaepe JA, Grimm HS, Hartmann T (2008). Cholesterol and A beta production: Methods for analysis of altered cholesterol De Novo synthesis, Advances in Alzheimer´s and Parkinson´s disease. Insights, Progress, and Perspectives, 221-230.

Grimm MO, Grimm HS, Tomic I, Beyreuther K, Hartmann T, Bergmann C (2008). Independent inhibition of Alzheimer disease beta- and gamma-secretase cleavage by lowered cholesterol levels, J Biol Chem, 283(17): 11302-11311. Pubmed

Hartmann T, Kuchenbecker J, Grimm MO (2007). Alzheimer's disease: the lipid connection, J Neurochem, 103 Suppl 1: 159-170. Pubmed

Grimm MO, Grimm HS, Hartmann T (2007). Amyloid beta as a regulator of lipid homeostasis, Trends Mol Med, 13(8): 337-344. Pubmed

Zinser EG, Hartmann T, Grimm MO (2007). Amyloid beta-protein and lipid metabolism, Biochim Biophys Acta, 1768(8): 1991-2001. Pubmed

Hartmann T, Fassbender K, Grimm MO (2007). Alzheimer´s disease prevention - The emerging role of lipids and diet OCL - Oleagineux Corps Gras Lipides Vol.14.

Grimm MO, Kuchenbecker J, Zinser EG, Hartmann T (2007). Plasmalogens and APP-Processing: Method for the Analysis of Altered Plasmalogen Homeostasis, in 8th International Conference on Alzheimer´s and Parkinson´s Disease AD/PD. (eds. A. Fisher & I. Hanin), 312-315. (Medimond International Proceedings, Salzburg, Austria)

Grimm MO, Tschape JA, Grimm HS, Zinser EG, Hartmann T (2006). Altered membrane fluidity and lipid raft composition in presenilin-deficient cells, Acta Neurol Scand Suppl. 185: 27-32. Pubmed

Grimm MO, Zinser EG, Grimm H, Wilk S, Müller U, Hartmann T (2006). Link between APP-processing, Alzheimer disease and Glycosphingolipid metabolism in 2nd ISN Special Neurochemistry Conference on Neural Glycoproteins and Glycolipids., Vol.99 (Antigua, West Indies)



2001 - 2005
Grimm MOW, Paetzold AJ, Grimm HS, Zinser EG, Ruppert T, Hartmann T (2005). Linking Alzheimer's disease, ß-Amyloid, and Lipids: a technical approach, CRC Press (Boca Raton, Florida)

Duering M, Grimm MO, Grimm HS, Schroder J, Hartmann T (2005). Mean age of onset in familial Alzheimer's disease is determined by amyloid beta 42, Neurobiol Aging, 26(6):785-788. Pubmed

Grimm MO, Grimm HS, Pätzold AJ, Zinser EG, Halonen R, Duering M, Tschäpe JA, De Strooper B, Müller U, Shen J, Hartmann T (2005). Regulation of cholesterol and sphingomyelin metabolism by amyloid-β and presenilin, Nature Cell Biol,7(11): 1118-1123. Pubmed

Grimm HS, Beher D, Lichtenthaler SF, Shearman MS, Beyreuther K, Hartmann T (2003). gamma-Secretase cleavage site specificity differs for intracellular and secretory amyloid beta, J Biol Chem, 278(15): 13077-13085. Pubmed

Grziwa B, Grimm MO, Masters CL, Beyreuther K, Hartmann T, Lichtenthaler SF (2003). The transmembrane domain of the amyloid precursor protein in microsomal membranes is on both sides shorter than predicted, J Biol Chem, 278(9): 6803-6808. Pubmed

Grimm MO, Tomic I, Hartmann T (2002). Potential external source of A beta in biological samples, Nat Cell Biol, 4(7): E164-165. Pubmed

Lichtenthaler SF, Beher D, Grimm HS, Wang R, Shearman MS, Masters CL, Beyreuther K (2001). The intramembrane cleavage site of the amyloid precursor protein depends on the length of its transmembrane domain, Proc Natl Acad Sci U S A, 99(3): 1365-1370. Pubmed

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